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Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome

For instance, a recent study has shown that GLS1 inhibition induces an increase in mitochondrial glutamate-pyruvate transaminase 2 (GPT2) to assist in TCA cycle anaplerosis for sustaining cancer cell growth and survival 152

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Enzymatic activity Glutathione transferase (GST)

The rationale was that these unregulated products pose severe health risks, including potential contamination with mould or bacteria, dosing errors, and life-threatening adverse reactions. The crackdown aligns with the implementation of New Zealands Medicines Amendment Act 2025 , which introduced a fast-track consent by verification pathway for legitimate pharmaceuticals